NAD+ metabolism governs the proinflammatory senescence-associated secretome
NAD+ metabolism governs the proinflammatory senescence-associated secretome
About this item
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Author / Creator
Nacarelli, Timothy , Lau, Lena , Fukumoto, Takeshi , Zundell, Joseph , Fatkhutdinov, Nail , Wu, Shuai , Aird, Katherine M. , Iwasaki, Osamu , Kossenkov, Andrew V. , Schultz, David , Noma, Ken-ichi , Baur, Joseph A. , Schug, Zachary , Tang, Hsin-Yao , Speicher, David W. , David, Gregory and Zhang, Rugang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). NAD
+
metabolism influences both tissue ageing and cancer. However, the role of NAD
+
metab...
Alternative Titles
Full title
NAD+ metabolism governs the proinflammatory senescence-associated secretome
Authors, Artists and Contributors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6448588
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6448588
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-019-0287-4
