Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Cas12a is a bacterial RNA-guided nuclease used widely for genome editing and, more recently, as a molecular diagnostic. In bacteria, Cas12a enzymes can be inhibited by bacteriophage-derived proteins, anti-CRISPRs (Acrs), to thwart clustered regularly interspaced short palindromic repeat (CRISPR) adaptive immune systems. How these inhibitors disable...
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Full title
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6449189
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6449189
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-019-0208-z
