Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation
Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we construct a core regulatory network of p53 dynamics comp...
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Full title
Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6458166
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6458166
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-41904-9
