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Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation

Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6458166

Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation

About this item

Full title

Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2019-04, Vol.9 (1), p.5883, Article 5883

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we construct a core regulatory network of p53 dynamics comp...

Alternative Titles

Full title

Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6458166

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6458166

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-019-41904-9

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