STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma
STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Plexiform neurofibroma, a benign peripheral nerve tumor, is associated with the biallelic loss of function of the
NF1
tumor suppressor in Schwann cells. Here, we show that FLLL32, a small molecule inhibitor of JAK2/STAT3 signaling, reduces neurofibroma growth in mice with conditional, biallelic deletion of
Nf1
in the Schwann cell lineag...
Alternative Titles
Full title
STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6461477
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6461477
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0600-x
