Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and co...
Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
About this item
Full title
Author / Creator
Schaffner, Adam , Li, Xianting , Gomez-Llorente, Yacob , Leandrou, Emmanouela , Memou, Anna , Clemente, Nicolina , Yao, Chen , Afsari, Farinaz , Zhi, Lianteng , Pan, Nina , Morohashi, Keita , Hua, Xiaoluan , Zhou, Ming-Ming , Wang, Chunyu , Zhang, Hui , Chen, Shu G. , Elliott, Christopher J. , Rideout, Hardy , Ubarretxena-Belandia, Iban and Yue, Zhenyu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Missense mutations in
Leucine-Rich Repeat Kinase 2
(LRRK2) cause the majority of familial and some sporadic forms of Parkinson’s disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therapeutics. Many potent and specific small-molec...
Alternative Titles
Full title
Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
Authors, Artists and Contributors
Author / Creator
Li, Xianting
Gomez-Llorente, Yacob
Leandrou, Emmanouela
Memou, Anna
Clemente, Nicolina
Yao, Chen
Afsari, Farinaz
Zhi, Lianteng
Pan, Nina
Morohashi, Keita
Hua, Xiaoluan
Zhou, Ming-Ming
Wang, Chunyu
Zhang, Hui
Chen, Shu G.
Elliott, Christopher J.
Rideout, Hardy
Ubarretxena-Belandia, Iban
Yue, Zhenyu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6462009
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6462009
Other Identifiers
ISSN
1001-0602,1748-7838
E-ISSN
1748-7838
DOI
10.1038/s41422-019-0153-8
