SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
About this item
Full title
Author / Creator
Zaslavsky, Kirill , Zhang, Wen-Bo , McCready, Fraser P. , Rodrigues, Deivid C. , Deneault, Eric , Loo, Caitlin , Zhao, Melody , Ross, P. Joel , El Hajjar, Joelle , Romm, Asli , Thompson, Tadeo , Piekna, Alina , Wei, Wei , Wang, Zhuozhi , Khattak, Shahryar , Mufteev, Marat , Pasceri, Peter , Scherer, Stephen W. , Salter, Michael W. and Ellis, James
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Heterozygous loss-of-function mutations in
SHANK2
are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced pluripotent stem cells derived from neurotypic and ASD-affected donors. We developed sparse coculture for connectivity assays where
SHANK2
and control neurons were differentially labeled and sp...
Alternative Titles
Full title
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
Authors, Artists and Contributors
Author / Creator
Zhang, Wen-Bo
McCready, Fraser P.
Rodrigues, Deivid C.
Deneault, Eric
Loo, Caitlin
Zhao, Melody
Ross, P. Joel
El Hajjar, Joelle
Romm, Asli
Thompson, Tadeo
Piekna, Alina
Wei, Wei
Wang, Zhuozhi
Khattak, Shahryar
Mufteev, Marat
Pasceri, Peter
Scherer, Stephen W.
Salter, Michael W.
Ellis, James
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6475597
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6475597
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-019-0365-8
