IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells
IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells
About this item
Full title
Author / Creator
Zhou, Yu‐Xi , Wang, Xin , Tang, Dan , Li, Yan , Jiao, Ying‐Fu , Gan, Yu , Hu, Xiao‐Ming , Yang, Li‐Qun , Yu, Wei‐Feng , Stetler, Ruth Anne , Li, Pei‐Ying and Wen, Da‐Xiang
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
England: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
Summary
Aims
Demyelination, one of the major pathological changes of white matter injury, is closely related to T‐cell–mediated immune responses. Thus, we investigate the role of an IL‐2 monoclonal antibody (IL‐2mAb, JES6‐1) in combatting demyelination during the late phase of stroke.
Methods
IL‐2mAb or IgG isotype antibody (0.25 mg/kg)...
Alternative Titles
Full title
IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6488908
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6488908
Other Identifiers
ISSN
1755-5930
E-ISSN
1755-5949
DOI
10.1111/cns.13084
