Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less select...
Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist
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United States: John Wiley and Sons Inc
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Language
English
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United States: John Wiley and Sons Inc
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Contents
Metabotropic glutamate receptors (mGluRs) are class C G protein coupled receptors with widespread expression in the central nervous system. There are eight mGluRs in the mammalian genome. Research on mGluRs relies on the availability of selective compounds. While many selective allosteric compounds have been described, selectivity of orthosteric ag...
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Full title
Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6498410
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6498410
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ISSN
2052-1707
E-ISSN
2052-1707
DOI
10.1002/prp2.471
