Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
About this item
Full title
Author / Creator
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: The American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Spastin and katanin sever and destabilize microtubules. Paradoxically, despite their destructive activity they increase microtubule mass in vivo. We combined single-molecule total internal reflection fluorescence microscopy and electron microscopy to show that the elemental step in microtubule severing is the generation of nanoscale damage througho...
Alternative Titles
Full title
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6510489
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6510489
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aau1504
