Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotempora...
Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
About this item
Full title
Author / Creator
Zhang, Yong-Jie , Gendron, Tania F. , Ebbert, Mark T. W. , O’Raw, Aliesha D. , Yue, Mei , Jansen-West, Karen , Zhang, Xu , Prudencio, Mercedes , Chew, Jeannie , Cook, Casey N. , Daughrity, Lillian M. , Tong, Jimei , Song, Yuping , Pickles, Sarah R. , Castanedes-Casey, Monica , Kurti, Aishe , Rademakers, Rosa , Oskarsson, Bjorn , Dickson, Dennis W. , Hu, Wenqian , Gitler, Aaron D. , Fryer, John D. and Petrucelli, Leonard
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a
C9orf72
G
4
C
2
repeat expansion
1
,
2
. Proposed mechanisms by which the expansion causes c9FTD/ALS include toxicity from repeat-containing RNA and from dipeptide repeat proteins translated from these transcripts. To...
Alternative Titles
Full title
Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Authors, Artists and Contributors
Author / Creator
Gendron, Tania F.
Ebbert, Mark T. W.
O’Raw, Aliesha D.
Yue, Mei
Jansen-West, Karen
Zhang, Xu
Prudencio, Mercedes
Chew, Jeannie
Cook, Casey N.
Daughrity, Lillian M.
Tong, Jimei
Song, Yuping
Pickles, Sarah R.
Castanedes-Casey, Monica
Kurti, Aishe
Rademakers, Rosa
Oskarsson, Bjorn
Dickson, Dennis W.
Hu, Wenqian
Gitler, Aaron D.
Fryer, John D.
Petrucelli, Leonard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6520050
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6520050
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0071-1
