Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
DNA mutations are known cancer drivers. Here we investigated whether mRNA events that are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA sequencing or 3′-end sequencing techniques were applied to normal and malignant B cells from 59 patients with chronic lymphocytic leukaemia (CLL)
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Full title
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6527314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6527314
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0465-8
