Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
About this item
Full title
Author / Creator
Sawant, Deepali V. , Yano, Hiroshi , Chikina, Maria , Zhang, Qianxia , Liao, Mengting , Liu, Chang , Callahan, Derrick J. , Sun, Zhe , Sun, Tao , Tabib, Tracy , Pennathur, Arjun , Corry, David B. , Luketich, James D. , Lafyatis, Robert , Chen, Wei , Poholek, Amanda C. , Bruno, Tullia C. , Workman, Creg J. and Vignali, Dario A. A.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Regulatory T cells (T
reg
cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. T
reg
cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expression on tumor-infiltrating lymphocytes (TILs); however, the underlying mediators and mechanisms have remained elusive. Here, w...
Alternative Titles
Full title
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6531353
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6531353
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-019-0346-9
