Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show tha...
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Full title
Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561242
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561242
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1903049116
