miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock
miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock
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Xue, Zhenyi , Xi, Qing , Liu, Hongkun , Guo, Xiangdong , Zhang, Jieyou , Zhang, Zimu , Li, Yan , Yang, Guangze , Zhou, Dongmei , Yang, Huiyun , Zhang, Lijuan , Zhang, Qi , Gu, Chao , Yang, Juhong , Da, Yurong , Yao, Zhi , Duo, Shuguang and Zhang, Rongxin
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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miR-21 is aberrantly expressed, and plays a role in various types of tumors and many other diseases. However, the mechanism of miR-21 in LPS-induced septic shock is still unclear. In this study, we investigated the mechanism of miR-21 in LPS-induced pyroptosis and septic shock. Here, we show that miR-21 deficiency inhibited NLRP3, ASC, and caspase-...
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Full title
miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561921
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561921
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-019-1713-z
