CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
About this item
Full title
Author / Creator
Pluvinage, John V. , Haney, Michael S. , Smith, Benjamin A. H. , Sun, Jerry , Iram, Tal , Bonanno, Liana , Li, Lulin , Lee, Davis P. , Morgens, David W. , Yang, Andrew C. , Shuken, Steven R. , Gate, David , Scott, Madeleine , Khatri, Purvesh , Luo, Jian , Bertozzi, Carolyn R. , Bassik, Michael C. and Wyss-Coray, Tony
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Microglia maintain homeostasis in the central nervous system through phagocytic clearance of protein aggregates and cellular debris. This function deteriorates during ageing and neurodegenerative disease, concomitant with cognitive decline. However, the mechanisms of impaired microglial homeostatic function and the cognitive effects of restoring th...
Alternative Titles
Full title
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6574119
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6574119
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1088-4
