Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption...
Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke
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Author / Creator
Chen, An-Qi , Fang, Zhi , Chen, Xiao-Lu , Yang, Shuai , Zhou, Yi-Fan , Mao, Ling , Xia, Yuan-Peng , Jin, Hui-Juan , Li, Ya-Nan , You, Ming-Feng , Wang, Xu-Xia , Lei, Hao , He, Quan-Wei and Hu, Bo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Endothelium (EC) is a key component of blood–brain barrier (BBB), and has an important position in the neurovascular unit. Its dysfunction and death after cerebral ischemic/reperfusion (I/R) injury not only promote evolution of neuroinflammation and brain edema, but also increase the risk of intracerebral hemorrhage of thrombolytic therapies. Howev...
Alternative Titles
Full title
Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6586814
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6586814
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-019-1716-9
