Central nervous system regeneration is driven by microglia necroptosis and repopulation
Central nervous system regeneration is driven by microglia necroptosis and repopulation
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Author / Creator
Lloyd, Amy F. , Davies, Claire L. , Holloway, Rebecca K. , Labrak, Yasmine , Ireland, Graeme , Carradori, Dario , Dillenburg, Alessandra , Borger, Eva , Soong, Daniel , Richardson, Jill C. , Kuhlmann, Tanja , Williams, Anna , Pollard, Jeffrey W. , des Rieux, Anne , Priller, Josef and Miron, Veronique E.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death an...
Alternative Titles
Full title
Central nervous system regeneration is driven by microglia necroptosis and repopulation
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6597360
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6597360
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-019-0418-z
