Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
About this item
Full title
Author / Creator
Omar, Faisa , Findlay, Jane E. , Carfray, Gemma , Allcock, Robert W. , Jiang, Zhong , Moore, Caitlin , Muir, Amy L. , Lannoy, Morgane , Fertig, Bracy A. , Mai, Deborah , Day, Jonathan P. , Bolger, Graeme , Baillie, George S. , Schwiebert, Erik , Klussmann, Enno , Pyne, Nigel J. , Ong, Albert C. M. , Bowers, Keith , Adam, Julia M. , Adams, David R. , Houslay, Miles D. and Henderson, David J. P.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Cyclic AMP (cAMP) phosphodiesterase-4 (PDE4) enzymes degrade cAMP and underpin the compartmentalization of cAMP signaling through their targeting to particular protein complexes and intracellular locales. We describe the discovery and characterization of a small-molecule compound that allosterically activates PDE4 long isoforms. This PDE4-specific...
Alternative Titles
Full title
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
Authors, Artists and Contributors
Author / Creator
Findlay, Jane E.
Carfray, Gemma
Allcock, Robert W.
Jiang, Zhong
Moore, Caitlin
Muir, Amy L.
Lannoy, Morgane
Fertig, Bracy A.
Mai, Deborah
Day, Jonathan P.
Bolger, Graeme
Baillie, George S.
Schwiebert, Erik
Klussmann, Enno
Pyne, Nigel J.
Ong, Albert C. M.
Bowers, Keith
Adam, Julia M.
Adams, David R.
Houslay, Miles D.
Henderson, David J. P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6613170
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6613170
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1822113116
