ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis
About this item
Full title
Author / Creator
Rotinen, Mirja , You, Sungyong , Yang, Julie , Coetzee, Simon G. , Reis-Sobreiro, Mariana , Huang, Wen-Chin , Huang, Fangjin , Pan, Xinlei , Yáñez, Alberto , Hazelett, Dennis J. , Chu, Chia-Yi , Steadman, Kenneth , Morrissey, Colm M. , Nelson, Peter S. , Corey, Eva , Chung, Leland W. K. , Freedland, Stephen J. , Di Vizio, Dolores , Garraway, Isla P. , Murali, Ramachandran , Knudsen, Beatrice S. and Freeman, Michael R.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Treatment of prostate cancer (PC) by androgen suppression promotes the emergence of aggressive variants that are androgen receptor (AR) independent. Here we identify the transcription factor ONECUT2 (OC2) as a master regulator of AR networks in metastatic castration-resistant prostate cancer (mCRPC). OC2 acts as a survival factor in mCRPC models, s...
Alternative Titles
Full title
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis
Authors, Artists and Contributors
Author / Creator
You, Sungyong
Yang, Julie
Coetzee, Simon G.
Reis-Sobreiro, Mariana
Huang, Wen-Chin
Huang, Fangjin
Pan, Xinlei
Yáñez, Alberto
Hazelett, Dennis J.
Chu, Chia-Yi
Steadman, Kenneth
Morrissey, Colm M.
Nelson, Peter S.
Corey, Eva
Chung, Leland W. K.
Freedland, Stephen J.
Di Vizio, Dolores
Garraway, Isla P.
Murali, Ramachandran
Knudsen, Beatrice S.
Freeman, Michael R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6614557
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6614557
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0241-1
