A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability
A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Neurons are sensitive to changes in the dosage of many genes, especially those regulating synaptic functions. Haploinsufficiency of
SHANK3
causes Phelan-McDermid syndrome and autism, whereas duplication of the same gene leads to
SHANK3
duplication syndrome, a disorder characterized by neuropsychiatric phenotypes including hyperactivity...
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Full title
A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6663662
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6663662
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-018-0325-9
