Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells
Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells
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Author / Creator
Song, Liqing , Yuan, Xuegang , Jones, Zachary , Vied, Cynthia , Miao, Yu , Marzano, Mark , Hua, Thien , Sang, Qing-Xiang Amy , Guan, Jingjiao , Ma, Teng , Zhou, Yi and Li, Yan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Current brain spheroids or organoids derived from human induced pluripotent stem cells (hiPSCs) still lack a microglia component, the resident immune cells in the brain. The objective of this study is to engineer brain region-specific organoids from hiPSCs incorporated with isogenic microglia-like cells in order to enhance immune function. In this...
Alternative Titles
Full title
Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6667451
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6667451
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-47444-6
