Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blo...
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
About this item
Full title
Author / Creator
Miller, Brian C. , Sen, Debattama R. , Al Abosy, Rose , Bi, Kevin , Virkud, Yamini V. , LaFleur, Martin W. , Yates, Kathleen B. , Lako, Ana , Felt, Kristen , Naik, Girish S. , Manos, Michael , Gjini, Evisa , Kuchroo, Juhi R. , Ishizuka, Jeffrey J. , Collier, Jenna L. , Griffin, Gabriel K. , Maleri, Seth , Comstock, Dawn E. , Weiss, Sarah A. , Brown, Flavian D. , Panda, Arpit , Zimmer, Margaret D. , Manguso, Robert T. , Hodi, F. Stephen , Rodig, Scott J. , Sharpe, Arlene H. and Haining, W. Nicholas
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fully understood. Here we show that such therapy acts on a specific subpopulation of exhausted CD8
+
tumor-infiltrating lymphocytes (TILs...
Alternative Titles
Full title
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
Authors, Artists and Contributors
Author / Creator
Sen, Debattama R.
Al Abosy, Rose
Bi, Kevin
Virkud, Yamini V.
LaFleur, Martin W.
Yates, Kathleen B.
Lako, Ana
Felt, Kristen
Naik, Girish S.
Manos, Michael
Gjini, Evisa
Kuchroo, Juhi R.
Ishizuka, Jeffrey J.
Collier, Jenna L.
Griffin, Gabriel K.
Maleri, Seth
Comstock, Dawn E.
Weiss, Sarah A.
Brown, Flavian D.
Panda, Arpit
Zimmer, Margaret D.
Manguso, Robert T.
Hodi, F. Stephen
Rodig, Scott J.
Sharpe, Arlene H.
Haining, W. Nicholas
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6673650
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6673650
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-019-0312-6
