Distinguishing genetic correlation from causation across 52 diseases and complex traits
Distinguishing genetic correlation from causation across 52 diseases and complex traits
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Mendelian randomization, a method to infer causal relationships, is confounded by genetic correlations reflecting shared etiology. We developed a model in which a latent causal variable mediates the genetic correlation; trait 1 is partially genetically causal for trait 2 if it is strongly genetically correlated with the latent causal variable, quan...
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Full title
Distinguishing genetic correlation from causation across 52 diseases and complex traits
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6684375
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6684375
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ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0255-0
