Clonal replacement of tumor-specific T cells following PD-1 blockade
Clonal replacement of tumor-specific T cells following PD-1 blockade
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Author / Creator
Yost, Kathryn E. , Satpathy, Ansuman T. , Wells, Daniel K. , Qi, Yanyan , Wang, Chunlin , Kageyama, Robin , McNamara, Katherine L. , Granja, Jeffrey M. , Sarin, Kavita Y. , Brown, Ryanne A. , Gupta, Rohit K. , Curtis, Christina , Bucktrout, Samantha L. , Davis, Mark M. , Chang, Anne Lynn S. and Chang, Howard Y.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the clinical care of patients with cancer
1
. However, whether the T cell response to checkpoint blockade relies on reinvigoration of pre-existing tumor-infiltrating lymphocytes or on recruitment of novel T cells remains unclear
2
–
4
. Here we...
Alternative Titles
Full title
Clonal replacement of tumor-specific T cells following PD-1 blockade
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6689255
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6689255
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-019-0522-3
