3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Widespread mRNA 3′ UTR shortening through alternative polyadenylation
1
promotes tumor growth in vivo
2
. A prevailing hypothesis is that it induces proto-oncogene expression in cis through escaping microRNA-mediated repression. Here we report a surprising enrichment of 3′UTR shortening among transcripts that are predicted to act as com...
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3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6689271
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6689271
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0118-8
