Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lu...
Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production
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Author / Creator
Fan, Jiajun , Zhang, Xuyao , Wang, Shaofei , Chen, Wei , Li, Yubin , Zeng, Xian , Wang, Yichen , Luan, Jingyun , Li, Li , Wang, Ziyu , Sun, Xilin , Shen, Baozhong and Ju, Dianwen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Lung adenocarcinoma (LUAD), which comprises over 50% of all cases of non-small-cell lung cancer, has a poor prognosis and requires novel therapeutic approaches. The sonic Hedgehog (Shh) pathway, which plays a crucial role in differentiation, proliferation, and survival of cancer cells, is likely to be activated in LUADs, suggesting the Shh pathway...
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Full title
Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6700102
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6700102
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-019-1840-6
