HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant K...
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Drug resistance and tumor heterogeneity are formidable challenges in cancer medicine, which is particularly relevant for
KRAS
-mutant cancers, the epitome of malignant tumors recalcitrant to targeted therapy efforts and first-line chemotherapy. In this study, we delineate that
KRAS
-mutant lung cancer cells resistant to pemetrexed (MTA)...
Alternative Titles
Full title
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6702198
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6702198
Other Identifiers
ISSN
2157-9024
E-ISSN
2157-9024
DOI
10.1038/s41389-019-0158-7
