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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6713202

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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Publisher

London: Nature Publishing Group UK

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Contents

Exhausted CD8
+
T (T
ex
) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared with effector (T
eff
) or memory (T
mem
) CD8
+
T cells. T
ex
cells are important clinical targets of checkpoint blockade and o...

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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6713202

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6713202

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ISSN

0028-0836,1476-4687

E-ISSN

1476-4687

DOI

10.1038/s41586-019-1325-x

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