Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues
Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues
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Author / Creator
Saka, Sinem K. , Wang, Yu , Kishi, Jocelyn Y. , Zhu, Allen , Zeng, Yitian , Xie, Wenxin , Kirli, Koray , Yapp, Clarence , Cicconet, Marcelo , Beliveau, Brian J. , Lapan, Sylvain W. , Yin, Siyuan , Lin, Millicent , Boyden, Edward S. , Kaeser, Pascal S. , Pihan, German , Church, George M. and Yin, Peng
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity and throughput. Here we report immunostaining with signal amplification by exchange reaction (Immuno-SABER), which achieves highly multiplexed signal amplification via DNA-barcoded antibodies and orthogonal DNA concatemers generated by primer exchange rea...
Alternative Titles
Full title
Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6728175
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6728175
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0207-y
