Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum ne...
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
About this item
Full title
Author / Creator
Flores, Alessandra , Ramirez-Franco, Jorge , Desplantes, Richard , Debreux, Kévin , Ferracci, Géraldine , Wernert, Florian , Blanchard, Marie-Pierre , Maulet, Yves , Youssouf, Fahamoe , Sangiardi, Marion , Iborra, Cécile , Popoff, Michel Robert , Seagar, Michael , Fantini, Jacques , Lévêque, Christian and Far, Oussama El
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor components: a polysialoganglioside, predominantly GT1b, and synaptotagmin 1/2. It is widely thought that BoNT/B initially binds to GT1b then diffuses in the plane of the membrane to interact with synaptotagmin. We have addressed the hypothesis that a GT1b–synap...
Alternative Titles
Full title
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6731659
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6731659
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1908051116
