Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive to...
Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Accumulative aggregation of mutant Huntingtin (Htt) is a primary neuropathological hallmark of Huntington’s disease (HD). Currently, mechanistic understanding of the cytotoxicity of mutant Htt aggregates remains limited, and neuroprotective strategies combating mutant Htt-induced neurodegeneration are lacking. Here, we show that in Drosophila model...
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Full title
Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6754563
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6754563
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1904563116
