Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
About this item
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Author / Creator
Minhas, Paras S. , Liu, Ling , Moon, Peter K. , Joshi, Amit U. , Dove, Christopher , Mhatre, Siddhita , Contrepois, Kevin , Wang, Qian , Lee, Brittany A. , Coronado, Michael , Bernstein, Daniel , Snyder, Michael P. , Migaud, Marie , Majeti, Ravindra , Mochly-Rosen, Daria , Rabinowitz, Joshua D. and Andreasson, Katrin I.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Recent advances highlight a pivotal role for cellular metabolism in programming immune responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine dinucleotide (NAD
+
) via the kynurenine pathway (KP) regulates macrophage immune function in aging and inflammation. Isotope tracer studies revealed that macrophage NAD...
Alternative Titles
Full title
Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6768398
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6768398
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0255-3
