PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Dros...
PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila
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Author / Creator
Fan, Jialin , Gao, Yajie , Lu, Yi , Wu, Wenqing , Yuan, Shuo , Wu, Hailong , Chen, Dahua and Zhao, Yun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Ptc is a gatekeeper to avoid abnormal Hh signaling activation, but the key regulators involved in Ptc-mediated inhibition remain largely unknown. Here, we identify PKAc as a key regulator required for Ptc inhibitory function. In the absence of Hh, PKAc physically interacts with Ptc and phosphorylates Ptc at Ser-1150 and -1183 residues. The presence...
Alternative Titles
Full title
PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6796939
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6796939
Other Identifiers
ISSN
2056-5968
E-ISSN
2056-5968
DOI
10.1038/s41421-019-0112-z
