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The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6824906

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Light-sheet microscopy is an ideal technique for imaging large cleared samples; however, the community is still lacking instruments capable of producing volumetric images of centimeter-sized cleared samples with near-isotropic resolution within minutes. Here, we introduce the mesoscale selective plane-illumination microscopy initiative, an open-hardware project for building and operating a light-sheet microscope that addresses these challenges and is compatible with any type of cleared or expanded sample (
www.mesospim.org
).
The mesoSPIM is an open hardware axially scanned light-sheet microscope for the rapid imaging of large cleared samples with isotropic resolution....

Alternative Titles

Full title

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6824906

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6824906

Other Identifiers

ISSN

1548-7091

E-ISSN

1548-7105

DOI

10.1038/s41592-019-0554-0

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