PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) has been shown to promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this “oncohistone” mutation acts by inhibiting the histone methyltransferase PRC2, the details of this proposed mechanism nevertheless continue to be debated. Recent evidence suggest...
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Full title
PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6825254
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6825254
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1911775116
