Structure of a Tc holotoxin pore provides insights into the translocation mechanism
Structure of a Tc holotoxin pore provides insights into the translocation mechanism
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Tc toxins are modular toxin systems of insect and human pathogenic bacteria. They are composed of a 1.4-MDa pentameric membrane translocator (TcA) and a 250-kDa cocoon (TcB and TcC) encapsulating the 30-kDa toxic enzyme (C terminus of TcC). Binding of Tc toxins to target cells and a pH shift trigger the conformational transition from the soluble pr...
Alternative Titles
Full title
Structure of a Tc holotoxin pore provides insights into the translocation mechanism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859359
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6859359
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1909821116
