Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout
Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Heat shock protein 47 (HSP47) is an endoplasmic reticulum (ER)-resident molecular chaperone that specifically recognizes triple helical portions of procollagens. The chaperone function of HSP47 is indispensable in mammals, and
hsp47
-null mice show an embryonic lethal phenotype accompanied by severe abnormalities in collagen-based tissue stru...
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Full title
Lowering the culture temperature corrects collagen abnormalities caused by HSP47 gene knockout
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6874656
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6874656
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-53962-0
