N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in...
N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice
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Author / Creator
Park, Min Hee , Lee, Misun , Nam, Geewoo , Kim, Mingeun , Kang, Juhye , Choi, Byung Jo , Jeong, Min Seock , Park, Kang Ho , Hui Han, Wan , Tak, Eunyoung , Kim, Min Sun , Lee, Juri , Lin, Yuxi , Lee, Young-Ho , Song, Im-Sook , Choi, Min-Koo , Lee, Joo-Yong , Jin, Hee Kyung , Bae, Jae-sung and Lim, Mi Hee
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
As a central feature of neuroinflammation, microglial dysfunction has been increasingly considered a causative factor of neurodegeneration implicating an intertwined pathology with amyloidogenic proteins. Herein, we report the smallest synthetic molecule (N,N′-diacetyl-p-phenylenediamine [DAPPD]), simply composed of a benzene ring with 2 acetamide...
Alternative Titles
Full title
N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6876236
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6876236
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1916318116
