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Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding p...

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding p...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6883791

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners

About this item

Full title

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-11, Vol.116 (48), p.24066-24074

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Histone variants fine-tune transcription, replication, DNA damage repair, and faithful chromosome segregation. Whether and how nucleosome variants encode unique mechanical properties to their cognate chromatin structures remains elusive. Here, using in silico and in vitro nanoindentation methods, extending to in vivo dissections, we report that his...

Alternative Titles

Full title

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6883791

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6883791

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1911880116

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