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Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate liga...

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate liga...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6911204

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding

About this item

Full title

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (50), p.25196-25202

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Chronic kidney disease (CKD) affects more than 20 million Americans and ∼10% of the population worldwide. Genome-wide association studies (GWAS) of kidney functional decline have identified genes associated with CKD, but the precise mechanisms by which they influence kidney function remained largely unexplored. Here, we examine the role of 1 GWAS-i...

Alternative Titles

Full title

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6911204

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6911204

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1909573116

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