Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key mod...
Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators
About this item
Full title
Author / Creator
Chi, Ximin , Gong, Deshun , Ren, Kang , Zhou, Gewei , Huang, Gaoxingyu , Lei, Jianlin , Zhou, Qiang and Yan, Nieng
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The type 2 ryanodine receptor (RyR2) is responsible for releasing Ca2+ from the sarcoplasmic reticulum of cardiomyocytes, subsequently leading to muscle contraction. Here, we report 4 cryo-electron microscopy (cryo-EM) structures of porcine RyR2 bound to distinct modulators that, together with our published structures, provide mechanistic insight i...
Alternative Titles
Full title
Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6926060
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6926060
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1914451116
