Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
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Author / Creator
Lalaoui, Najoua , Boyden, Steven E. , Oda, Hirotsugu , Wood, Geryl M. , Stone, Deborah L. , Chau, Diep , Liu, Lin , Stoffels, Monique , Kratina, Tobias , Lawlor, Kate E. , Zaal, Kristien J. M. , Hoffmann, Patrycja M. , Etemadi, Nima , Shield-Artin, Kristy , Biben, Christine , Tsai, Wanxia Li , Blake, Mary D. , Kuehn, Hye Sun , Yang, Dan , Anderton, Holly , Silke, Natasha , Wachsmuth, Laurens , Zheng, Lixin , Moura, Natalia Sampaio , Beck, David B. , Gutierrez-Cruz, Gustavo , Ombrello, Amanda K. , Pinto-Patarroyo, Gineth P. , Kueh, Andrew J. , Herold, Marco J. , Hall, Cathrine , Wang, Hongying , Chae, Jae Jin , Dmitrieva, Natalia I. , McKenzie, Mark , Light, Amanda , Barham, Beverly K. , Jones, Anne , Romeo, Tina M. , Zhou, Qing , Aksentijevich, Ivona , Mullikin, James C. , Gross, Andrew J. , Shum, Anthony K. , Hawkins, Edwin D. , Masters, Seth L. , Lenardo, Michael J. , Boehm, Manfred , Rosenzweig, Sergio D. , Pasparakis, Manolis , Voss, Anne K. , Gadina, Massimo , Kastner, Daniel L. and Silke, John
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage
1
–
7
. The physiological relevance of this cleavage event remains unclear, although...
Alternative Titles
Full title
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Authors, Artists and Contributors
Author / Creator
Boyden, Steven E.
Oda, Hirotsugu
Wood, Geryl M.
Stone, Deborah L.
Chau, Diep
Liu, Lin
Stoffels, Monique
Kratina, Tobias
Lawlor, Kate E.
Zaal, Kristien J. M.
Hoffmann, Patrycja M.
Etemadi, Nima
Shield-Artin, Kristy
Biben, Christine
Tsai, Wanxia Li
Blake, Mary D.
Kuehn, Hye Sun
Yang, Dan
Anderton, Holly
Silke, Natasha
Wachsmuth, Laurens
Zheng, Lixin
Moura, Natalia Sampaio
Beck, David B.
Gutierrez-Cruz, Gustavo
Ombrello, Amanda K.
Pinto-Patarroyo, Gineth P.
Kueh, Andrew J.
Herold, Marco J.
Hall, Cathrine
Wang, Hongying
Chae, Jae Jin
Dmitrieva, Natalia I.
McKenzie, Mark
Light, Amanda
Barham, Beverly K.
Jones, Anne
Romeo, Tina M.
Zhou, Qing
Aksentijevich, Ivona
Mullikin, James C.
Gross, Andrew J.
Shum, Anthony K.
Hawkins, Edwin D.
Masters, Seth L.
Lenardo, Michael J.
Boehm, Manfred
Rosenzweig, Sergio D.
Pasparakis, Manolis
Voss, Anne K.
Gadina, Massimo
Kastner, Daniel L.
Silke, John
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6930849
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6930849
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1828-5
