Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synth...
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
About this item
Full title
Author / Creator
Che, Li , Chi, Wenna , Qiao, Yu , Zhang, Jie , Song, Xinhua , Liu, Ye , Li, Lei , Jia, Jiaoyuan , Pilo, Maria G , Wang, Jingxiao , Cigliano, Antonio , Ma, Zhilong , Kuang, Wenhua , Tang, Zefang , Zhang, Zemin , Shui, Guanghou , Ribback, Silvia , Dombrowski, Frank , Evert, Matthias , Pascale, Rosa Maria , Cossu, Carla , Pes, Giovanni Mario , Osborne, Timothy F , Calvisi, Diego F , Chen, Xin and Chen, Ligong
Publisher
England: BMJ Publishing Group LTD
Journal title
Language
English
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Publication information
Publisher
England: BMJ Publishing Group LTD
Subjects
More information
Scope and Contents
Contents
ObjectiveIncreased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC).DesignWe investigated the functional contribution of fatty acid synthase (Fasn)-mediated de novo FA synthesis in a murine HCC model induced by loss of Pten and overexpress...
Alternative Titles
Full title
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
Authors, Artists and Contributors
Author / Creator
Chi, Wenna
Qiao, Yu
Zhang, Jie
Song, Xinhua
Liu, Ye
Li, Lei
Jia, Jiaoyuan
Pilo, Maria G
Wang, Jingxiao
Cigliano, Antonio
Ma, Zhilong
Kuang, Wenhua
Tang, Zefang
Zhang, Zemin
Shui, Guanghou
Ribback, Silvia
Dombrowski, Frank
Evert, Matthias
Pascale, Rosa Maria
Cossu, Carla
Pes, Giovanni Mario
Osborne, Timothy F
Calvisi, Diego F
Chen, Xin
Chen, Ligong
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6943247
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6943247
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2018-317581
