Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficien...
Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency
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Full title
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Versatile and precise genome modifications are needed to create a wider range of adoptive cellular therapies
1
–
5
. Here we report two improvements that increase the efficiency of CRISPR–Cas9-based genome editing in clinically relevant primary cell types. Truncated Cas9 target sequences (tCTSs) added at the ends of the homology-directe...
Alternative Titles
Full title
Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6954310
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6954310
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0325-6
