A causal mechanism for childhood acute lymphoblastic leukaemia
A causal mechanism for childhood acute lymphoblastic leukaemia
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation by fusion gene formation or hyperdiploidy generates a covert, pre-leukaemic clone. Second, in a small fraction of these cases,...
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Full title
A causal mechanism for childhood acute lymphoblastic leukaemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6986894
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6986894
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/s41568-018-0015-6