Innate immune receptor NOD2 mediates LGR5⁺ intestinal stem cell protection against ROS cytotoxicity...
Innate immune receptor NOD2 mediates LGR5⁺ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation
About this item
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)⁺ intestinal stem cell (ISC) survival through NOD2 activation upon an otherwise lethal oxidative stress-mediated signal. H...
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Full title
Innate immune receptor NOD2 mediates LGR5⁺ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6994981
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6994981
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1902788117
