Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative...
Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathy
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Publisher
Vienna: Springer Vienna
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Language
English
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Publisher
Vienna: Springer Vienna
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The existence of more than 30 strains of transmissible spongiform encephalopathy (TSE) and the paucity of infectivity of purified PrP
Sc
, as well as considerations of PrP structure, are inconsistent with the protein-only (prion) theory of TSE. Nucleic acid is a strong contender as a second component. We juxtapose two key findings: (i) PrP is...
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Full title
Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7024060
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7024060
Other Identifiers
ISSN
0304-8608
E-ISSN
1432-8798
DOI
10.1007/s00705-020-04529-2
