Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation
Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
A long-standing mystery shrouds the mechanism by which catalytically repressed receptor tyrosine kinase domains accomplish transphosphorylation of activation loop (A-loop) tyrosines. Here we show that this reaction proceeds via an asymmetric complex that is thermodynamically disadvantaged because of an electrostatic repulsion between enzyme and sub...
Alternative Titles
Full title
Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7040854
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7040854
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-019-0455-7
