Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenate...
Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Accurate quantification of synaptic changes is essential for understanding the molecular mechanisms of synaptogenesis, synaptic plasticity, and synaptic toxicity. Here we demonstrate a robust high-content imaging method for the assessment of synaptic changes and apply the method to brain homogenates from an Alzheimer’s disease mouse model. Our meth...
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Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7042280
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7042280
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-60118-y
