APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE M...
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
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Author / Creator
Area-Gomez, Estela , Larrea, Delfina , Pera, Marta , Agrawal, Rishi R. , Guilfoyle, David N. , Pirhaji, Leila , Shannon, Kathleen , Arain, Hirra A. , Ashok, Archana , Chen, Qiuying , Dillman, Allissa A. , Figueroa, Helen Y. , Cookson, Mark R. , Gross, Steven S. , Fraenkel, Ernest , Duff, Karen E. and Nuriel, Tal
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The ε4 allele of apolipoprotein E (
APOE
) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association between
APOE4
and AD remains unclear. While much of the research has focused on the ability of the apoE4 protein to increase the aggregation and decrease the clearance of Aβ, the...
Alternative Titles
Full title
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7062695
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7062695
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-61142-8
